WHAT IS AZELAIC ACID AND HOW DOES IT WORK?
Azelaic acid – a popular active ingredient in dermatology due to its wide range of therapeutic applications. And the global market for products containing azelaic acid is growing steadily, driven by increasing demand for effective treatments for acne, rosacea, and hyperpigmentation. Azelaic acid has a wide range of effects. It can have antioxidant, keratolytic, and anti-inflammatory effects, as well as helping to even out skin tone in cases of redness. It is precisely this versatility that makes the active ingredient so popular. If you are wondering what azelaic acid is or how it affects the skin, you will find a complete overview here – scientifically sound and ideal for your daily routine.
Azelaic acid belongs to the dicarboxylic acids and occurs naturally in wheat, barley, sunflower oil, and rye. However, a synthetic variant can also be used in skin care products. The effect of azelaic acid on the skin is based on several properties:
- It can inhibit the release of reactive oxygen species (ROS), thereby reducing oxidative stress in the skin.
- Azelaic acid can help combat pimples, as it can inhibit the growth of the bacterium Cutibacterium acnes, which is found in increased numbers on the skin in cases of pimples and acne. It has a keratolytic effect by regulating excessive keratinization of the skin.
- It can have anti-inflammatory and anti-melanogenic effects. Azelaic acid can inhibit melanin formation through several mechanisms, such as by inhibiting tyrosinase and regulating overactive melanocytes. It can therefore be used to treat hyperpigmentation such as melasma and post-inflammatory hyperpigmentation (PIH).
- Azelaic acid can modulate inflammatory signaling pathways and reduce the formation of pro-inflammatory cytokines, which supports its use in inflammatory skin conditions such as rosacea and acne.
It is precisely this combination that makes it an active ingredient that can be used effectively on oily and blemished skin as well as sensitive skin and uneven complexions. Unlike many other acids, it does not make the skin more sensitive to light and can therefore be used daily if well tolerated.
Are you wondering what percentage of azelaic acid is appropriate? Concentrations of up to 10% can have effects that are particularly helpful for blemishes, especially if you have troubled skin. Higher concentrations of 15–20% are available on prescription and are used in dermatology for skin conditions such as acne and rosacea.






