Palmitoyl Tripeptide-38 is a synthetic tripeptide used in cosmetics as a skin care ingredient for well-aging. As a matrikine-like peptide, it can address signaling pathways in the extracellular matrix and thus smooth the skin structure: Manufacturer data reports a visible reduction in wrinkles (e.g., forehead, crow's feet) with regular use. Palmitoyl Tripeptide-38 is a so-called matrix peptide that stimulates the production of important components of the skin matrix, including collagen I, III, and IV, as well as hyaluronic acid.(1) These structures ensure the elasticity and firmness of the skin. In clinical studies, palmitoyl tripeptide-38 was shown to visibly reduce wrinkle depth. In formulations, it therefore serves to maintain good skin condition and a more even skin texture. (1-3)