Hyaluronic acid is one of the primary factors in skin hydration, along with lipids, natural moisturizing factors, sebum, and aquaporin. As the predominant component in the extracellular matrix, hyaluronic acid plays an essential role in maintaining skin hydration. Hyaluronic acid is formed early in embryonic development, making it one of the first extracellular matrix components. In addition to its ability to bind water, the molecule acts as a lubricant for skin movements between the collagen and elastic fiber networks in the dermis. Hyaluronic acid can also influence cell metabolism.