ASCORBYL TETRAISOPALMITATE
Ascorbyl tetraisopalmitate is a vitamin C derivative and is used in cosmetics to prevent skin aging due to its antioxidant properties.(1) It has a high affinity for the stratum corneum of human skin and is also able to promote collagen synthesis in the deeper cells. (2-3) In a study from 2021, in combination with other substances such as rice peptides, it was able to increase skin moisture, reduce hyperpigmentation, and promote cell renewal in the epidermis. (4)
(1) Almeida, M., Lima, C., Quenca-Guillen, J., Filho, E., Mercuri, L., Santoro, M., & Kedor-Hackmann, É. (2010). Stability evaluation of tocopheryl acetate and ascorbyl tetraisopalmitate in isolation and incorporated in cosmetic formulations using thermal analysis. Brazilian Journal of Pharmaceutical Sciences, 46, 129-134.
(2) Machado, N., Santos, L., Carvalho, B., Singh, P., Soto, C., Azoia, N., Cavaco-Paulo, A., Martin, A., & Fávero, P. (2016). Assessment of penetration of Ascorbyl Tetraisopalmitate into biological membranes by molecular dynamics. Computers in biology and medicine, 75, 151-9.
(3) Dulińska-Molak, I., Pasikowska-Piwko, M., Dȩbowska, R., Świȩszkowski, W., Rogiewicz, K., & Eris, I. (2019). Determining the effectiveness of vitamin C in skin care by atomic force microscope. Microscopy Research and Technique, 82, 1430-1437.
(4) Shirata, M., & Campos, P. (2021). Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study. Photochemistry and Photobiology, 97.
